Assay Detail
Binding
CHEMBL2065355
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Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease A156T mutant expressed in Escherichia coli by time-resolved fluorescence analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus (isolate BK) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.83 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2063088 | — | — | 1 | 8.62 |
| CHEMBL2063089 | — | — | 1 | 8.54 |
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | 4.0 | 1 | 8.28 |
| CHEMBL2063087 | — | — | 1 | 7.92 |
| CHEMBL2063085 | — | — | 1 | 7.75 |
| CHEMBL4525964 | VANIPREVIR | 3.0 | 1 | 7.66 |
| CHEMBL2063086 | — | — | 1 | 7.57 |
| CHEMBL1672609 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2063088 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL2063089 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL2063090 | GRAZOPREVIR ANHYDROUS | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL2063087 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL2063085 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL4525964 | VANIPREVIR | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL2063086 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL1672609 | — | Ki | = | 540.0 | nM | 6.27 |