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Assay Detail

CHEMBL2065576

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]SR141716A form human CB1 receptor expressed in HEK293 cells after 60 mins by beta counting
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cannabinoid receptor 1 (CHEMBL218)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design of a Potent CB1 Receptor Antagonist Series: Potential Scaffold for Peripherally-Targeted Agents.
Dow RL, Carpino PA, Gautreau D, Hadcock JR, Iredale PA, Kelly-Sullivan D, Lizano JS, O'Connor RE, Schneider SR, Scott DO, Ward KM.
ACS Med Chem Lett (2012) 3 : 397 -401
PubMed 24900484 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 23 9.07 10.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2063240 1 10.05
CHEMBL2063245 1 9.92
CHEMBL2063246 1 9.89
CHEMBL2063237 1 9.85
CHEMBL2063236 1 9.80
CHEMBL2063243 1 9.60
CHEMBL2063244 1 9.59
CHEMBL2063235 1 9.39
CHEMBL2063250 1 9.27
CHEMBL2063248 1 9.26
CHEMBL2063242 1 9.25
CHEMBL2063239 1 9.23
CHEMBL2063122 1 9.12
CHEMBL484929 1 9.00
CHEMBL2063252 1 9.00
CHEMBL2063241 1 8.85
CHEMBL2063247 1 8.80
CHEMBL2063249 1 8.77
CHEMBL111 RIMONABANT 4.0 1 8.74
CHEMBL2063251 1 8.35
CHEMBL2063238 1 8.29
CHEMBL2063121 1 7.34
CHEMBL2063120 1 7.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2063240 Ki = 0.09 nM 10.05
CHEMBL2063245 Ki = 0.12 nM 9.92
CHEMBL2063246 Ki = 0.13 nM 9.89
CHEMBL2063237 Ki = 0.14 nM 9.85
CHEMBL2063236 Ki = 0.16 nM 9.80
CHEMBL2063243 Ki = 0.25 nM 9.60
CHEMBL2063244 Ki = 0.26 nM 9.59
CHEMBL2063235 Ki = 0.41 nM 9.39
CHEMBL2063250 Ki = 0.54 nM 9.27
CHEMBL2063248 Ki = 0.55 nM 9.26
CHEMBL2063242 Ki = 0.56 nM 9.25
CHEMBL2063239 Ki = 0.59 nM 9.23
CHEMBL2063122 Ki = 0.75 nM 9.12
CHEMBL484929 Ki = 1.0 nM 9.00
CHEMBL2063252 Ki = 1.0 nM 9.00
CHEMBL2063241 Ki = 1.4 nM 8.85
CHEMBL2063247 Ki = 1.6 nM 8.80
CHEMBL2063249 Ki = 1.7 nM 8.77
CHEMBL111 RIMONABANT Ki = 1.8 nM 8.74
CHEMBL2063251 Ki = 4.5 nM 8.35
CHEMBL2063238 Ki = 5.1 nM 8.29
CHEMBL2063121 Ki = 46.0 nM 7.34
CHEMBL2063120 Ki = 57.0 nM 7.24