Compound Detail
CHEMBL2063121
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Basic Information
| ChEMBL ID | CHEMBL2063121 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZDGJVKASQPXDJF-UHFFFAOYSA-N |
| Parent Compound | CHEMBL2079193 |
| Active Moiety | CHEMBL2079193 |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
4
Publications
0
Known Names
Molecular Properties
388.3
MW (Da)
5.28
ALogP
4
HBA
1
HBD
39.1
PSA (Ų)
0.66
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 7.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cannabinoid receptor 1 CHEMBL218 | Ki | 7.34 | 7.34 | 46.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 54.0 | mL.min-1.kg-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cannabinoid receptor 1 | Ki | = | 46.0 | nM | 7.34 | Displacement of [3H]SR141716A form human CB1 receptor expressed in HEK293 cells ... | 24900484 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900484 | 10.1021/ml3000325 | MDCK | 2 |
| 24900484 | 10.1021/ml3000325 | Liver microsomes | 1 |
| 24900484 | 10.1021/ml3000325 | Cannabinoid receptor 2 | 1 |
| 24900484 | 10.1021/ml3000325 | Cannabinoid receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine