Assay Detail
Binding
CHEMBL2065780
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of human MMP9 using fluorogenic substrate by Dixon plot analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship for Thiirane-Based Gelatinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.63 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1651842 | — | — | 1 | 8.30 |
| CHEMBL2063270 | — | — | 1 | 7.36 |
| CHEMBL2063274 | — | — | 1 | 6.80 |
| CHEMBL2063276 | — | — | 1 | 6.80 |
| CHEMBL2063272 | — | — | 1 | 6.54 |
| CHEMBL2063273 | — | — | 1 | 6.41 |
| CHEMBL2063275 | — | — | 1 | 6.33 |
| CHEMBL483857 | — | — | 1 | 6.22 |
| CHEMBL2063277 | — | — | 1 | 6.03 |
| CHEMBL2063271 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1651842 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL2063270 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL2063274 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL2063276 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL2063272 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL2063273 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL2063275 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL483857 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL2063277 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL2063271 | — | Ki | = | 3000.0 | nM | 5.52 |