Assay Detail
Binding
CHEMBL2066007
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human plasmatic BChE using butylthiocholne substrate preincubated for 5 mins before substrate addition by Ellman's method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.77 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1677 | TACRINE HYDROCHLORIDE | 4.0 | 1 | 7.64 |
| CHEMBL2064466 | — | — | 1 | 7.47 |
| CHEMBL2064465 | — | — | 1 | 7.38 |
| CHEMBL2064464 | — | — | 1 | 7.20 |
| CHEMBL2064404 | — | — | 1 | 7.11 |
| CHEMBL2064469 | — | — | 1 | 6.90 |
| CHEMBL2064468 | — | — | 1 | 6.86 |
| CHEMBL2064470 | — | — | 1 | 6.68 |
| CHEMBL2064471 | — | — | 1 | 5.82 |
| CHEMBL1256415 | — | — | 1 | 4.68 |
| CHEMBL2064467 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1677 | TACRINE HYDROCHLORIDE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2064466 | — | IC50 | = | 33.7 | nM | 7.47 |
| CHEMBL2064465 | — | IC50 | = | 41.2 | nM | 7.38 |
| CHEMBL2064464 | — | IC50 | = | 63.7 | nM | 7.20 |
| CHEMBL2064404 | — | IC50 | = | 77.8 | nM | 7.11 |
| CHEMBL2064469 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL2064468 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL2064470 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL2064471 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL1256415 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL2064467 | — | IC50 | - | — | - |