Assay Detail
Binding
CHEMBL2066264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human voltage-dependent L-type calcium channel subunit alpha1C/alpha2delta/beta2a expressed in C1-6-37-3 cells assessed as inhibition of K+-induced calcium influx incubated for 30 mins prior to K+-induction by Fluo-4-AM based FLIPR assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Isolation and structural elucidation of cyclic tetrapeptides from Onychocola sclerotica.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.98 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL475534 | NITRENDIPINE | 3.0 | 1 | 8.52 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 6.05 |
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | 5.66 |
| CHEMBL2063169 | — | — | 1 | 5.30 |
| CHEMBL2063167 | — | — | 1 | 5.21 |
| CHEMBL2063168 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL475534 | NITRENDIPINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL23 | DILTIAZEM | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2063169 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2063167 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL2063168 | — | IC50 | = | 7100.0 | nM | 5.15 |