Assay Detail
Functional
CHEMBL2066301
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated MCP1 expression up to 10 uM by quantitative RT-PCR analysis
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 2 | - | - |
| IC50 | 2 | 6.30 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256279 | BENGAMIDE A | — | 2 | 6.30 |
| CHEMBL446079 | BENGAMIDE B | — | 2 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256279 | BENGAMIDE A | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL446079 | BENGAMIDE B | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL256279 | BENGAMIDE A | Activity | - | — | - | |
| CHEMBL446079 | BENGAMIDE B | Activity | - | — | - |