Assay Detail
Functional
CHEMBL2066643
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human C3a receptor expressed in RBL-2H3 cells assessed as beta-hexosaminidase activity in cell supernatant compound preincubated for 10 mins by degranulation assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RBL-2H3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
C3a anaphylatoxin chemotactic receptor (CHEMBL4761) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
De novo peptide design with C3a receptor agonist and antagonist activities: theoretical predictions and experimental validation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.91 | 8.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2064013 | — | — | 1 | 8.73 |
| CHEMBL2064017 | — | — | 1 | 8.34 |
| CHEMBL2064014 | — | — | 1 | 8.30 |
| CHEMBL2064015 | — | — | 1 | 8.11 |
| CHEMBL2064016 | — | — | 1 | 8.04 |
| CHEMBL2064012 | — | — | 1 | 7.96 |
| CHEMBL2064021 | — | — | 1 | 7.91 |
| CHEMBL2064018 | — | — | 1 | 7.81 |
| CHEMBL2064011 | — | — | 1 | 7.63 |
| CHEMBL2064019 | — | — | 1 | 7.58 |
| CHEMBL2063898 | — | — | 1 | 7.30 |
| CHEMBL2064020 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2064013 | — | IC50 | = | 1.862 | nM | 8.73 |
| CHEMBL2064017 | — | IC50 | = | 4.571 | nM | 8.34 |
| CHEMBL2064014 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL2064015 | — | IC50 | = | 7.762 | nM | 8.11 |
| CHEMBL2064016 | — | IC50 | = | 9.12 | nM | 8.04 |
| CHEMBL2064012 | — | IC50 | = | 10.96 | nM | 7.96 |
| CHEMBL2064021 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL2064018 | — | IC50 | = | 15.49 | nM | 7.81 |
| CHEMBL2064011 | — | IC50 | = | 23.44 | nM | 7.63 |
| CHEMBL2064019 | — | IC50 | = | 26.3 | nM | 7.58 |
| CHEMBL2063898 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL2064020 | — | IC50 | = | 63.1 | nM | 7.20 |