Assay Detail
Binding
CHEMBL2066844
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Inhibition of human DPP8 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to addition of substrate measured after 30 mins
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-Substituted boro-proline dipeptides: synthesis, characterization, and dipeptidyl peptidase IV, 8, and 9 activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.03 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2063040 | — | — | 1 | 8.92 |
| CHEMBL2063033 | — | — | 1 | 8.23 |
| CHEMBL2063024 | — | — | 1 | 8.04 |
| CHEMBL63860 | — | — | 1 | 7.89 |
| CHEMBL2063031 | — | — | 1 | 7.77 |
| CHEMBL2063037 | — | — | 1 | 7.72 |
| CHEMBL2063026 | — | — | 1 | 7.64 |
| CHEMBL2063035 | — | — | 1 | 7.57 |
| CHEMBL2063032 | — | — | 1 | 7.37 |
| CHEMBL2063029 | — | — | 1 | 7.27 |
| CHEMBL2063034 | — | — | 1 | 6.96 |
| CHEMBL2063039 | — | — | 1 | 6.94 |
| CHEMBL2063030 | — | — | 1 | 6.50 |
| CHEMBL2063025 | — | — | 1 | 6.32 |
| CHEMBL2063036 | — | — | 1 | 6.30 |
| CHEMBL2063027 | — | — | 1 | 6.29 |
| CHEMBL2063038 | — | — | 1 | 6.28 |
| CHEMBL393336 | — | — | 1 | 4.96 |
| CHEMBL2063028 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2063040 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2063033 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL2063024 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL63860 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2063031 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2063037 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2063026 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2063035 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2063032 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2063029 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL2063034 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2063039 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL2063030 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2063025 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL2063036 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2063027 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL2063038 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL393336 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2063028 | — | IC50 | = | 27000.0 | nM | 4.57 |