Compound Detail
CHEMBL2063035
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Basic Information
| ChEMBL ID | CHEMBL2063035 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YQHVRHHVEWIRMK-KVPKETBZSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
244.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.03
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dipeptidyl peptidase 9 CHEMBL4793 | IC50 | 8.03 | 8.03 | 9.3 | 1 |
| Dipeptidyl peptidase 4 CHEMBL284 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
| Dipeptidyl peptidase 8 CHEMBL4657 | IC50 | 7.57 | 7.57 | 27.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dipeptidyl peptidase 9 | IC50 | = | 9.3 | nM | 8.03 | Inhibition of human DPP9 expressed in HEK293 cells using Ala-Pro-p-nitroanilide ... | 22853995 |
| Dipeptidyl peptidase 4 | IC50 | = | 20.0 | nM | 7.7 | Inhibition of human DPP4 expressed in HEK293 cells using Ala-Pro-p-nitroanilide ... | 22853995 |
| Dipeptidyl peptidase 8 | IC50 | = | 27.0 | nM | 7.57 | Inhibition of human DPP8 expressed in HEK293 cells using Ala-Pro-p-nitroanilide ... | 22853995 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22853995 | 10.1016/j.bmcl.2012.07.033 | Dipeptidyl peptidase 4 | 1 |
| 22853995 | 10.1016/j.bmcl.2012.07.033 | Dipeptidyl peptidase 8 | 1 |
| 22853995 | 10.1016/j.bmcl.2012.07.033 | Dipeptidyl peptidase 9 | 1 |
Data from ChEMBL 36 via Core Engine