Assay Detail
Binding
CHEMBL2066845
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Inhibition of human DPP9 expressed in HEK293 cells using Ala-Pro-p-nitroanilide hydrochloride salt as substrate preincubated for 10 mins prior to addition of substrate measured after 30 mins
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-Substituted boro-proline dipeptides: synthesis, characterization, and dipeptidyl peptidase IV, 8, and 9 activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.42 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2063040 | — | — | 1 | 9.51 |
| CHEMBL2063033 | — | — | 1 | 8.68 |
| CHEMBL63860 | — | — | 1 | 8.55 |
| CHEMBL2063024 | — | — | 1 | 8.46 |
| CHEMBL2063031 | — | — | 1 | 8.19 |
| CHEMBL2063035 | — | — | 1 | 8.03 |
| CHEMBL2063037 | — | — | 1 | 8.02 |
| CHEMBL2063026 | — | — | 1 | 7.96 |
| CHEMBL2063032 | — | — | 1 | 7.85 |
| CHEMBL2063029 | — | — | 1 | 7.46 |
| CHEMBL2063039 | — | — | 1 | 7.40 |
| CHEMBL2063030 | — | — | 1 | 7.07 |
| CHEMBL2063034 | — | — | 1 | 7.01 |
| CHEMBL2063025 | — | — | 1 | 6.90 |
| CHEMBL2063027 | — | — | 1 | 6.75 |
| CHEMBL2063036 | — | — | 1 | 6.70 |
| CHEMBL2063038 | — | — | 1 | 6.62 |
| CHEMBL2063028 | — | — | 1 | 5.16 |
| CHEMBL393336 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2063040 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL2063033 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL63860 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL2063024 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL2063031 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL2063035 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL2063037 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL2063026 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2063032 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2063029 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2063039 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2063030 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL2063034 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL2063025 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL2063027 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2063036 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2063038 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2063028 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL393336 | — | IC50 | = | 20000.0 | nM | 4.70 |