Assay Detail
Functional
CHEMBL2066974
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Antiviral activity against HSV1 KOS infected in HEL cells by viral CPE assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.59 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2063192 | — | — | 1 | 8.10 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 7.57 |
| CHEMBL2063194 | — | — | 1 | 7.47 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 7.42 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 6.28 |
| CHEMBL2063195 | — | — | 1 | 6.18 |
| CHEMBL419692 | — | — | 1 | 6.11 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 6.03 |
| CHEMBL2063188 | — | — | 1 | 5.86 |
| CHEMBL2063190 | — | — | 1 | 4.92 |
| CHEMBL2063185 | — | — | 1 | - |
| CHEMBL2063186 | — | — | 1 | - |
| CHEMBL2063187 | — | — | 1 | - |
| CHEMBL2063189 | — | — | 1 | - |
| CHEMBL2063191 | — | — | 1 | - |
| CHEMBL2063193 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2063192 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2063194 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL31634 | BRIVUDINE | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL2063195 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL419692 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL2063188 | — | EC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL2063190 | — | EC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL2063185 | — | EC50 | > | 117000.0 | nM | - |
| CHEMBL2063186 | — | EC50 | > | 115000.0 | nM | - |
| CHEMBL2063187 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL2063189 | — | EC50 | > | 115000.0 | nM | - |
| CHEMBL2063191 | — | EC50 | > | 6800.0 | nM | - |
| CHEMBL2063193 | — | EC50 | > | 7000.0 | nM | - |