Assay Detail
Functional
CHEMBL2066976
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against thymidine kinase negative and ACV resistant HSV1 KOS infected in HEL cells by viral CPE assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.01 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2063192 | — | — | 1 | 7.92 |
| CHEMBL2063194 | — | — | 1 | 7.05 |
| CHEMBL2063195 | — | — | 1 | 6.30 |
| CHEMBL419692 | — | — | 1 | 6.11 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 5.76 |
| CHEMBL2063188 | — | — | 1 | 5.55 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 4.83 |
| CHEMBL2063190 | — | — | 1 | 4.52 |
| CHEMBL2063185 | — | — | 1 | - |
| CHEMBL2063186 | — | — | 1 | - |
| CHEMBL2063187 | — | — | 1 | - |
| CHEMBL2063189 | — | — | 1 | - |
| CHEMBL2063191 | — | — | 1 | - |
| CHEMBL2063193 | — | — | 1 | - |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | - |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2063192 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2063194 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2063195 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL419692 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL2063188 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL2063190 | — | EC50 | = | 30500.0 | nM | 4.52 |
| CHEMBL2063185 | — | EC50 | > | 117000.0 | nM | - |
| CHEMBL2063186 | — | EC50 | > | 115000.0 | nM | - |
| CHEMBL2063187 | — | EC50 | > | 35000.0 | nM | - |
| CHEMBL2063189 | — | EC50 | > | 115000.0 | nM | - |
| CHEMBL2063191 | — | EC50 | > | 6800.0 | nM | - |
| CHEMBL2063193 | — | EC50 | > | 7000.0 | nM | - |
| CHEMBL31634 | BRIVUDINE | EC50 | >= | 183000.0 | nM | - |
| CHEMBL184 | ACYCLOVIR | EC50 | >= | 212000.0 | nM | - |