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Assay Detail

CHEMBL2067378

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity at Escherichia coli UTI89 FimH assessed as inhibition of aggregation with guinea pig erythrocytes after 1400 secs by aggregometry
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Escherichia coli
Confidence 1 — Organism
Curated By Autocuration

Target

Escherichia coli (CHEMBL354)
Type ORGANISM
Organism Escherichia coli

Publication

Antiadhesion therapy for urinary tract infections--a balanced PK/PD profile proved to be key for success.
Jiang X, Abgottspon D, Kleeb S, Rabbani S, Scharenberg M, Wittwer M, Haug M, Schwardt O, Ernst B.
J Med Chem (2012) 55 : 4700 -4713
PubMed 22519985 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 5.00 5.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2064305 1 5.89
CHEMBL2064314 1 5.51
CHEMBL2064321 1 5.47
CHEMBL2064311 1 5.39
CHEMBL2064310 1 5.30
CHEMBL2064316 1 5.25
CHEMBL2064308 1 5.19
CHEMBL2064312 1 5.15
CHEMBL2064318 1 5.09
CHEMBL2064304 1 5.08
CHEMBL1802185 1 5.00
CHEMBL2064323 1 4.72
CHEMBL2064317 1 4.64
CHEMBL2064325 1 4.60
CHEMBL2064319 1 4.57
CHEMBL2064309 1 4.53
CHEMBL2064324 1 4.45
CHEMBL1170455 1 4.11
CHEMBL2064313 1 -
CHEMBL2064315 1 -
CHEMBL2064307 1 -
CHEMBL2064306 1 -
CHEMBL2064320 1 -
CHEMBL2064322 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2064305 IC50 = 1300.0 nM 5.89
CHEMBL2064314 IC50 = 3100.0 nM 5.51
CHEMBL2064321 IC50 = 3400.0 nM 5.47
CHEMBL2064311 IC50 = 4100.0 nM 5.39
CHEMBL2064310 IC50 = 5000.0 nM 5.30
CHEMBL2064316 IC50 = 5600.0 nM 5.25
CHEMBL2064308 IC50 = 6400.0 nM 5.19
CHEMBL2064312 IC50 = 7100.0 nM 5.15
CHEMBL2064318 IC50 = 8200.0 nM 5.09
CHEMBL2064304 IC50 = 8300.0 nM 5.08
CHEMBL1802185 IC50 = 10000.0 nM 5.00
CHEMBL2064323 IC50 = 19200.0 nM 4.72
CHEMBL2064317 IC50 = 23100.0 nM 4.64
CHEMBL2064325 IC50 = 25300.0 nM 4.60
CHEMBL2064319 IC50 = 26900.0 nM 4.57
CHEMBL2064309 IC50 = 29500.0 nM 4.53
CHEMBL2064324 IC50 = 35900.0 nM 4.45
CHEMBL1170455 IC50 = 77100.0 nM 4.11
CHEMBL2064313 IC50 - -
CHEMBL2064315 IC50 - -
CHEMBL2064307 IC50 - -
CHEMBL2064306 IC50 - -
CHEMBL2064320 IC50 - -
CHEMBL2064322 IC50 - -