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Assay Detail

CHEMBL2067429

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ADMET
Cytotoxicity against CHO cells by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Cricetulus griseus
Cell Type CHO
Confidence 1 — Organism
Curated By Autocuration

Target

CHO (CHEMBL613853)
Type CELL-LINE
Organism Cricetulus griseus

Publication

Synthesis and in vitro antimalarial activity of a series of bisquinoline and bispyrrolo[1,2a]quinoxaline compounds.
van Heerden L, Cloete TT, Breytenbach JW, de Kock C, Smith PJ, Breytenbach JC, N'Da DD.
Eur J Med Chem (2012) 55 : 335 -345
PubMed 22889556 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.41 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL50588 EMETINE 4.0 1 6.52
CHEMBL42527 1 5.58
CHEMBL2063628 1 5.55
CHEMBL342178 1 5.51
CHEMBL2063629 1 5.42
CHEMBL60070 1 5.37
CHEMBL138071 1 5.11
CHEMBL2063620 1 5.10
CHEMBL2063630 1 5.09
CHEMBL2063621 1 4.89
CHEMBL2063624 1 -
CHEMBL2063627 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL50588 EMETINE IC50 = 300.0 nM 6.52
CHEMBL42527 IC50 = 2610.0 nM 5.58
CHEMBL2063628 IC50 = 2800.0 nM 5.55
CHEMBL342178 IC50 = 3100.0 nM 5.51
CHEMBL2063629 IC50 = 3800.0 nM 5.42
CHEMBL60070 IC50 = 4300.0 nM 5.37
CHEMBL138071 IC50 = 7800.0 nM 5.11
CHEMBL2063620 IC50 = 8010.0 nM 5.10
CHEMBL2063630 IC50 = 8100.0 nM 5.09
CHEMBL2063621 IC50 = 12970.0 nM 4.89
CHEMBL2063624 IC50 = 132120.0 nM -
CHEMBL2063627 IC50 = 173990.0 nM -