Assay Detail
Binding
CHEMBL2071884
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE5
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL2304402) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
Novel triazines as potent and selective phosphodiesterase 10A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.63 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2069321 | — | — | 1 | 6.36 |
| CHEMBL2070655 | — | — | 1 | 6.22 |
| CHEMBL2070654 | — | — | 1 | 6.19 |
| CHEMBL2070641 | — | — | 1 | 6.15 |
| CHEMBL2070649 | — | — | 1 | 5.96 |
| CHEMBL2070632 | — | — | 1 | 5.94 |
| CHEMBL2070651 | — | — | 1 | 5.84 |
| CHEMBL2070639 | — | — | 1 | 5.78 |
| CHEMBL2070668 | — | — | 1 | 5.67 |
| CHEMBL2070666 | — | — | 1 | 5.64 |
| CHEMBL2070671 | — | — | 1 | 5.56 |
| CHEMBL2070648 | — | — | 1 | 5.51 |
| CHEMBL2070634 | — | — | 1 | 5.47 |
| CHEMBL2070664 | — | — | 1 | 5.44 |
| CHEMBL2070647 | — | — | 1 | 5.43 |
| CHEMBL2070669 | — | — | 1 | 5.40 |
| CHEMBL2070665 | — | — | 1 | 5.32 |
| CHEMBL2070653 | — | — | 1 | 5.30 |
| CHEMBL2070652 | — | — | 1 | 5.29 |
| CHEMBL2070656 | — | — | 1 | 5.27 |
| CHEMBL2070633 | — | — | 1 | 4.47 |
| CHEMBL2070650 | — | — | 1 | - |
| CHEMBL2070670 | — | — | 1 | - |
| CHEMBL2070667 | — | — | 1 | - |
| CHEMBL2070640 | — | — | 1 | - |
| CHEMBL2070646 | — | — | 1 | - |
| CHEMBL2070663 | — | — | 1 | - |
| CHEMBL2070662 | — | — | 1 | - |
| CHEMBL2070661 | — | — | 1 | - |
| CHEMBL2070660 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2069321 | — | IC50 | = | 436.0 | nM | 6.36 |
| CHEMBL2070655 | — | IC50 | = | 603.0 | nM | 6.22 |
| CHEMBL2070654 | — | IC50 | = | 651.0 | nM | 6.19 |
| CHEMBL2070641 | — | IC50 | = | 702.0 | nM | 6.15 |
| CHEMBL2070649 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL2070632 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL2070651 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL2070639 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL2070668 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL2070666 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL2070671 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL2070648 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL2070634 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL2070664 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2070647 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL2070669 | — | IC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL2070665 | — | IC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL2070653 | — | IC50 | = | 4950.0 | nM | 5.30 |
| CHEMBL2070652 | — | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL2070656 | — | IC50 | = | 5380.0 | nM | 5.27 |
| CHEMBL2070633 | — | IC50 | = | 34100.0 | nM | 4.47 |
| CHEMBL2070645 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2070631 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2070657 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2070658 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2070659 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2070660 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2070661 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2070662 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2070663 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2070646 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2070640 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2070667 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2070670 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2070650 | — | IC50 | > | 1000.0 | nM | - |