cGMP-specific 3',5'-cyclic phosphodiesterase · SINGLE PROTEIN · Canis lupus familiaris
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As of 2026-09-13Protein identity stays anchored to UniProt O77746. Use UniProt O77746 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O77746 as the stable identity anchor, then attach disease evidence before program review.
cGMP-specific 3',5'-cyclic phosphodiesterase
Review this target as cGMP-specific 3',5'-cyclic phosphodiesterase, mapped to UniProt O77746. Sequence length is 865 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats cGMP-specific 3',5'-cyclic phosphodiesterase as ChEMBL target CHEMBL2304402, mapped to UniProt O77746. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether cGMP-specific 3',5'-cyclic phosphodiesterase is the right protein anchor across sources, using UniProt O77746 as the stable mapping.
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| Preferred Name | cGMP-specific 3',5'-cyclic phosphodiesterase |
| Target Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
| UniProt | O77746 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | cGMP-specific 3',5'-cyclic phosphodiesterase |
| UniProt Accession | O77746 |
| Component Type | Protein |
| Sequence Length | 865 aa |
cGMP-specific 3',5'-cyclic phosphodiesterase
Review this target as cGMP-specific 3',5'-cyclic phosphodiesterase, mapped to UniProt O77746. Sequence length is 865 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3338455 | 10.28 | IC50 | 0.053 | Preclinical |
| CHEMBL3338445 | 9.89 | IC50 | 0.13 | Preclinical |
| CHEMBL3404016 | 9.68 | IC50 | 0.21 | Preclinical |
| CHEMBL538498 | 9.66 | IC50 | 0.22 | Preclinical |
| CHEMBL540031 | 9.66 | IC50 | 0.22 | Preclinical |
| CHEMBL540294 | 9.64 | IC50 | 0.23 | Preclinical |
| CHEMBL541822 | 9.54 | IC50 | 0.29 | Preclinical |
| CHEMBL77795 | 9.51 | IC50 | 0.31 | Preclinical |
| CHEMBL542409 | 9.42 | IC50 | 0.38 | Preclinical |
| CHEMBL3338448 | 9.42 | IC50 | 0.38 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 13 | 152 | 7.4 |
| assay format | 2 | 0 | — |
| cell-based format | 1 | 0 | — |