Compound Detail
CHEMBL542409
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COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccc(OCc3ccccn3)nc2c(=O)n1Cc1ccncc1.Cl
Basic Information
| ChEMBL ID | CHEMBL542409 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KCMWNSNTOAECCZ-UHFFFAOYSA-N |
| Parent Compound | CHEMBL1191330 |
| Active Moiety | CHEMBL1191330 |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
568.6
MW (Da)
4.29
ALogP
11
HBA
0
HBD
123.9
PSA (Ų)
0.23
QED
2
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL2304402 | IC50 | 9.42 | 9.42 | 0.4 | 1 |
| Phosphodiesterase 6 CHEMBL2096979 | IC50 | 7.96 | 7.96 | 11.0 | 1 |
| Phosphodiesterase 1 CHEMBL2095150 | IC50 | 4.35 | 4.35 | 45000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 0.38 | nM | 9.42 | Inhibitory activity against phosphodiesterase 5 (PDE5) isolated from canine lung | 12824030 |
| Phosphodiesterase 6 | IC50 | = | 11.0 | nM | 7.96 | Inhibitory activity against Phosphodiesterase 6 isolated from bovine retina | 12824030 |
| Phosphodiesterase 1 | IC50 | = | 45000.0 | nM | 4.35 | Inhibitory activity against phosphodiesterase-1 (PDE1) isolated from canine lung | 12824030 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12824030 | 10.1016/s0960-894x(03)00440-2 | Phosphodiesterase 1 | 1 |
| 12824030 | 10.1016/s0960-894x(03)00440-2 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
| 12824030 | 10.1016/s0960-894x(03)00440-2 | Phosphodiesterase 6 | 1 |
Data from ChEMBL 36 via Core Engine