Assay Detail
Binding
CHEMBL763667
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Inhibitory activity against phosphodiesterase 5 (PDE5) isolated from canine lung
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL2304402) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
1,7- and 2,7-naphthyridine derivatives as potent and highly specific PDE5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.93 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL540031 | — | — | 1 | 9.66 |
| CHEMBL540294 | — | — | 1 | 9.64 |
| CHEMBL541822 | — | — | 1 | 9.54 |
| CHEMBL77795 | — | — | 1 | 9.51 |
| CHEMBL542409 | — | — | 1 | 9.42 |
| CHEMBL553729 | — | — | 1 | 9.29 |
| CHEMBL539783 | — | — | 1 | 9.28 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 9.00 |
| CHEMBL77971 | — | — | 1 | 9.00 |
| CHEMBL539357 | — | — | 1 | 8.92 |
| CHEMBL1202833 | — | — | 1 | 8.74 |
| CHEMBL542410 | — | — | 1 | 8.72 |
| CHEMBL539266 | — | — | 1 | 8.64 |
| CHEMBL541823 | — | — | 1 | 8.59 |
| CHEMBL539778 | — | — | 1 | 7.96 |
| CHEMBL77893 | — | — | 1 | 7.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL540031 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL540294 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL541822 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL77795 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL542409 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL553729 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL539783 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL77971 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL539357 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1202833 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL542410 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL539266 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL541823 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL539778 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL77893 | — | IC50 | = | 94.0 | nM | 7.03 |