Assay Detail
Binding
CHEMBL760836
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Inhibitory activity against Phosphodiesterase 6 isolated from bovine retina
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
1,7- and 2,7-naphthyridine derivatives as potent and highly specific PDE5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.41 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77795 | — | — | 1 | 8.36 |
| CHEMBL541822 | — | — | 1 | 8.11 |
| CHEMBL540031 | — | — | 1 | 8.07 |
| CHEMBL542409 | — | — | 1 | 7.96 |
| CHEMBL553729 | — | — | 1 | 7.66 |
| CHEMBL1202833 | — | — | 1 | 7.66 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 7.55 |
| CHEMBL77971 | — | — | 1 | 7.55 |
| CHEMBL539266 | — | — | 1 | 7.42 |
| CHEMBL542410 | — | — | 1 | 7.38 |
| CHEMBL540294 | — | — | 1 | 7.25 |
| CHEMBL539783 | — | — | 1 | 7.14 |
| CHEMBL539778 | — | — | 1 | 6.64 |
| CHEMBL541823 | — | — | 1 | 6.55 |
| CHEMBL77893 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77795 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL541822 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL540031 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL542409 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL553729 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1202833 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL77971 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL539266 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL542410 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL540294 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL539783 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL539778 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL541823 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL77893 | — | IC50 | = | 1400.0 | nM | 5.85 |