Phosphodiesterase 6 · PROTEIN FAMILY · Bos taurus
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As of 2026-09-14Protein identity stays anchored to UniProt P23439. Use UniProt P23439 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P23439 as the stable identity anchor, then attach disease evidence before program review.
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Review this target as Phosphodiesterase 6, mapped to UniProt P23439. ChEMBL maps the protein component as Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta. Sequence length is 853 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Phosphodiesterase 6 as ChEMBL target CHEMBL2096979, mapped to UniProt P23439. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Phosphodiesterase 6 is the right protein anchor across sources, using UniProt P23439 as the stable mapping.
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| Preferred Name | Phosphodiesterase 6 |
| Target Type | PROTEIN FAMILY |
| Organism | Bos taurus |
| UniProt | P23439 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta |
| UniProt Accession | P23439 |
| Component Type | Protein |
| Sequence Length | 853 aa |
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Review this target as Phosphodiesterase 6, mapped to UniProt P23439. ChEMBL maps the protein component as Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta. Sequence length is 853 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL245317 | 8.59 | IC50 | 2.58 | Preclinical |
| CHEMBL315477 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL77795 | 8.36 | IC50 | 4.4 | Preclinical |
| CHEMBL87202 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL541822 | 8.11 | IC50 | 7.7 | Preclinical |
| CHEMBL540031 | 8.07 | IC50 | 8.6 | Preclinical |
| CHEMBL542409 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL327772 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL314849 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL433418 | 7.8 | IC50 | 16.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 11 | 37 | 6.7 |
| tissue-based format | 3 | 28 | 7.0 |