Assay Detail
Binding
CHEMBL2072019
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human KIAA1363 expressed in 293T/17 cells using 2-thioacetyl MAGE as substrate preincubated for 4 hrs measured after 1 hr
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neutral cholesterol ester hydrolase 1 (CHEMBL5048) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1/AADACL1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.12 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2069333 | — | — | 1 | 7.00 |
| CHEMBL2071656 | — | — | 1 | 6.48 |
| CHEMBL2071659 | — | — | 1 | 6.15 |
| CHEMBL2069332 | — | — | 1 | 5.96 |
| CHEMBL2071658 | — | — | 1 | 5.82 |
| CHEMBL2071626 | — | — | 1 | 5.77 |
| CHEMBL2071657 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2069333 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2071656 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2071659 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL2069332 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2071658 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2071626 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2071657 | — | IC50 | = | 2200.0 | nM | 5.66 |