Assay Detail
Functional
CHEMBL2072188
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Antiproliferative activity against human RCC4/VHL cells after 96 hrs by SRB assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RCC4/VHL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.39 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2069620 | — | — | 1 | 5.62 |
| CHEMBL2069710 | — | — | 1 | 5.62 |
| CHEMBL2069706 | — | — | 1 | 5.58 |
| CHEMBL2069708 | — | — | 1 | 5.58 |
| CHEMBL2069618 | — | — | 1 | 5.57 |
| CHEMBL2069707 | — | — | 1 | 5.57 |
| CHEMBL2069621 | — | — | 1 | 5.19 |
| CHEMBL2069619 | — | — | 1 | 5.17 |
| CHEMBL2069709 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2069620 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2069710 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2069706 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2069708 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2069618 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2069707 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2069621 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL2069619 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL2069709 | — | IC50 | = | 26000.0 | nM | 4.58 |