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Assay Detail

CHEMBL2072341

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antioxidant activity in Wistar rat brain homogenates assessed as inhibition of lipid peroxidation by spectrophotometry based TBARS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Brain
Confidence 1 — Organism
Curated By Autocuration

Target

Brain (CHEMBL613617)
Type TISSUE
Organism Rattus norvegicus

Publication

Synthesis, cytotoxic and antioxidant evaluations of amino derivatives from perezone.
Concepción Lozada M, Soria-Arteche O, Ramírez Apan MT, Nieto-Camacho A, Enríquez RG, Izquierdo T, Jiménez-Corona A.
Bioorg Med Chem (2012) 20 : 5077 -5084
PubMed 22858298 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.81 5.83

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL50 QUERCETIN 3.0 1 5.83
CHEMBL2071237 1 5.25
CHEMBL47 ALPHA-TOCOPHEROL 1 5.17
CHEMBL2071239 1 4.83
CHEMBL2071241 1 4.71
CHEMBL2071240 1 4.69
CHEMBL2071238 1 4.65
CHEMBL2001361 ISOPEREZONE 1 4.63
CHEMBL2071242 1 4.60
CHEMBL2071236 1 4.56
CHEMBL2071235 1 4.53
CHEMBL2071234 PEREZONE 1 4.31

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL50 QUERCETIN IC50 = 1496.0 nM 5.83
CHEMBL2071237 IC50 = 5564.0 nM 5.25
CHEMBL47 ALPHA-TOCOPHEROL IC50 = 6780.0 nM 5.17
CHEMBL2071239 IC50 = 14670.0 nM 4.83
CHEMBL2071241 IC50 = 19330.0 nM 4.71
CHEMBL2071240 IC50 = 20250.0 nM 4.69
CHEMBL2071238 IC50 = 22440.0 nM 4.65
CHEMBL2001361 ISOPEREZONE IC50 = 23260.0 nM 4.63
CHEMBL2071242 IC50 = 25160.0 nM 4.60
CHEMBL2071236 IC50 = 27440.0 nM 4.56
CHEMBL2071235 IC50 = 29750.0 nM 4.53
CHEMBL2071234 PEREZONE IC50 = 49220.0 nM 4.31