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Target Snapshot

CHEMBL613617 Target Snapshot

Brain · TISSUE · Rattus norvegicus

Back to Search Search this target Browse approvals Evidence Card
2,227Compounds
1,781Assays
2Approved Drugs
259.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Brain as ChEMBL target CHEMBL613617. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Brain
TISSUE · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL613617
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Brain still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameBrain
Target TypeTISSUE
OrganismRattus norvegicus
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBrain
UniProt AccessionN/A

Brain

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Brain.

Review nameBrain
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

2
Approved
2
Phase III
4
Phase II
Assay Mix

Activity Type Distribution

IC50226.0
EC5033.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL492438 6.77 IC50 170.0 Preclinical
CHEMBL254274 6.58 IC50 260.0 Preclinical
CHEMBL254072 6.57 IC50 270.0 Preclinical
CHEMBL252807 6.54 IC50 290.0 Preclinical
CHEMBL3745877 6.48 IC50 330.0 Preclinical
CHEMBL253649 6.44 IC50 360.0 Preclinical
CHEMBL2260665 6.41 IC50 390.0 Preclinical
CHEMBL253228 6.39 IC50 410.0 Preclinical
CHEMBL399863 6.38 IC50 420.0 Preclinical
CHEMBL253873 6.36 IC50 440.0 Preclinical
Distribution

pChEMBL Value Distribution

56
5.0
26
5.5
10
6.0
4
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1,781
Total Assays
194
Tested Compounds
3
Assay Types
ADME — 1,636 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 1,407 1 6.8
tissue-based format 224 0 —
cell membrane format 2 0 —
cell-based format 2 0 —
cell-free format 1 0 —
Functional — 144 assays, 194 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 120 177 5.1
organism-based format 13 5 4.2
subcellular format 11 12 4.5
Toxicity — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine