Assay Detail
Binding
CHEMBL2072999
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant GST-tagged PI3K p110beta using [32P]ATP after 60 mins by scintillation proximity assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.16 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2071341 | — | — | 1 | 7.05 |
| CHEMBL2069328 | — | — | 1 | 6.60 |
| CHEMBL2071342 | — | — | 1 | 6.50 |
| CHEMBL1986603 | — | — | 1 | 6.47 |
| CHEMBL2071333 | — | — | 1 | 6.39 |
| CHEMBL2071329 | — | — | 1 | 6.26 |
| CHEMBL2071331 | — | — | 1 | 6.12 |
| CHEMBL2071340 | — | — | 1 | 6.07 |
| CHEMBL2071332 | — | — | 1 | 6.06 |
| CHEMBL2071328 | — | — | 1 | 5.89 |
| CHEMBL2071327 | — | — | 1 | 5.87 |
| CHEMBL2071330 | — | — | 1 | 5.85 |
| CHEMBL2071326 | — | — | 1 | 5.84 |
| CHEMBL2071334 | — | — | 1 | 5.71 |
| CHEMBL2071338 | — | — | 1 | 5.70 |
| CHEMBL2071337 | — | — | 1 | - |
| CHEMBL2071336 | — | — | 1 | - |
| CHEMBL2071335 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2071341 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL2069328 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL2071342 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL1986603 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL2071333 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL2071329 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL2071331 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL2071340 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL2071332 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL2071328 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL2071327 | — | Ki | = | 1360.0 | nM | 5.87 |
| CHEMBL2071330 | — | Ki | = | 1410.0 | nM | 5.85 |
| CHEMBL2071326 | — | Ki | = | 1430.0 | nM | 5.84 |
| CHEMBL2071334 | — | Ki | = | 1940.0 | nM | 5.71 |
| CHEMBL2071338 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL2071337 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2071336 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2071335 | — | Ki | > | 10000.0 | nM | - |