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Assay Detail

CHEMBL2073335

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of CYP1A2
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cytochrome P450 1A2 (CHEMBL3356)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis and identification of novel benzimidazole derivatives as highly potent NPY Y5 receptor antagonists with attractive in vitro ADME profiles.
Tamura Y, Omori N, Kouyama N, Nishiura Y, Hayashi K, Watanabe K, Tanaka Y, Chiba T, Yukioka H, Sato H, Okuno T.
Bioorg Med Chem Lett (2012) 22 : 5498 -5502
PubMed 22853998 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 5.76 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2070142 1 6.40
CHEMBL2070137 1 6.40
CHEMBL2070153 1 6.40
CHEMBL2070154 1 6.40
CHEMBL2070150 1 6.40
CHEMBL2070146 1 5.96
CHEMBL2070155 1 5.80
CHEMBL2070143 1 5.72
CHEMBL2070147 1 5.66
CHEMBL2070140 1 5.57
CHEMBL2070138 1 5.54
CHEMBL2070149 1 5.52
CHEMBL2069316 1 5.50
CHEMBL2070157 1 5.47
CHEMBL2070148 1 5.47
CHEMBL2070156 1 5.20
CHEMBL2070152 1 5.11
CHEMBL2070151 1 5.07
CHEMBL2070163 1 -
CHEMBL1585484 1 -
CHEMBL2070141 1 -
CHEMBL2070162 1 -
CHEMBL2070139 1 -
CHEMBL2070158 1 -
CHEMBL2070159 1 -
CHEMBL2070160 1 -
CHEMBL2070161 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2070142 IC50 = 400.0 nM 6.40
CHEMBL2070137 IC50 = 400.0 nM 6.40
CHEMBL2070153 IC50 = 400.0 nM 6.40
CHEMBL2070154 IC50 = 400.0 nM 6.40
CHEMBL2070150 IC50 = 400.0 nM 6.40
CHEMBL2070146 IC50 = 1100.0 nM 5.96
CHEMBL2070155 IC50 = 1600.0 nM 5.80
CHEMBL2070143 IC50 = 1900.0 nM 5.72
CHEMBL2070147 IC50 = 2200.0 nM 5.66
CHEMBL2070140 IC50 = 2700.0 nM 5.57
CHEMBL2070138 IC50 = 2900.0 nM 5.54
CHEMBL2070149 IC50 = 3000.0 nM 5.52
CHEMBL2069316 IC50 = 3200.0 nM 5.50
CHEMBL2070157 IC50 = 3400.0 nM 5.47
CHEMBL2070148 IC50 = 3400.0 nM 5.47
CHEMBL2070156 IC50 = 6300.0 nM 5.20
CHEMBL2070152 IC50 = 7800.0 nM 5.11
CHEMBL2070151 IC50 = 8500.0 nM 5.07
CHEMBL2070163 IC50 > 20000.0 nM -
CHEMBL1585484 IC50 > 20000.0 nM -
CHEMBL2070141 IC50 > 20000.0 nM -
CHEMBL2070162 IC50 > 20000.0 nM -
CHEMBL2070139 IC50 > 20000.0 nM -
CHEMBL2070158 IC50 > 20000.0 nM -
CHEMBL2070159 IC50 > 20000.0 nM -
CHEMBL2070160 IC50 > 20000.0 nM -
CHEMBL2070161 IC50 > 20000.0 nM -