Assay Detail
ADMET
CHEMBL2073336
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Inhibition of CYP2C19
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and identification of novel benzimidazole derivatives as highly potent NPY Y5 receptor antagonists with attractive in vitro ADME profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.00 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1585484 | — | — | 1 | 6.40 |
| CHEMBL2070153 | — | — | 1 | 5.38 |
| CHEMBL2070150 | — | — | 1 | 5.31 |
| CHEMBL2070141 | — | — | 1 | 5.23 |
| CHEMBL2070160 | — | — | 1 | 5.04 |
| CHEMBL2070149 | — | — | 1 | 5.03 |
| CHEMBL2070143 | — | — | 1 | 5.00 |
| CHEMBL2070138 | — | — | 1 | 4.89 |
| CHEMBL2070146 | — | — | 1 | 4.89 |
| CHEMBL2070152 | — | — | 1 | 4.85 |
| CHEMBL2070155 | — | — | 1 | 4.85 |
| CHEMBL2070156 | — | — | 1 | 4.82 |
| CHEMBL2070137 | — | — | 1 | 4.77 |
| CHEMBL2070142 | — | — | 1 | 4.77 |
| CHEMBL2070148 | — | — | 1 | 4.77 |
| CHEMBL2069316 | — | — | 1 | 4.75 |
| CHEMBL2070154 | — | — | 1 | 4.75 |
| CHEMBL2070140 | — | — | 1 | 4.72 |
| CHEMBL2070147 | — | — | 1 | 4.72 |
| CHEMBL2070163 | — | — | 1 | - |
| CHEMBL2070139 | — | — | 1 | - |
| CHEMBL2070162 | — | — | 1 | - |
| CHEMBL2070151 | — | — | 1 | - |
| CHEMBL2070157 | — | — | 1 | - |
| CHEMBL2070158 | — | — | 1 | - |
| CHEMBL2070159 | — | — | 1 | - |
| CHEMBL2070161 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1585484 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2070153 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL2070150 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL2070141 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL2070160 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL2070149 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL2070143 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2070138 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2070146 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2070152 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2070155 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2070156 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2070137 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL2070142 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL2070148 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL2069316 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL2070154 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL2070140 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL2070147 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL2070163 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2070139 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2070162 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2070151 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2070157 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2070158 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2070159 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2070161 | — | IC50 | > | 20000.0 | nM | - |