Assay Detail
Binding
CHEMBL2073499
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Inhibition of Aurora B kinase by HTRF analysis in presence of 1 mM ATP
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.44 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1980297 | ILORASERTIB | 2.0 | 1 | 8.15 |
| CHEMBL2071216 | — | — | 1 | 8.10 |
| CHEMBL2071210 | — | — | 1 | 8.10 |
| CHEMBL2071276 | — | — | 1 | 7.92 |
| CHEMBL2071275 | — | — | 1 | 7.92 |
| CHEMBL2071217 | — | — | 1 | 7.92 |
| CHEMBL2071277 | — | — | 1 | 7.82 |
| CHEMBL2071199 | — | — | 1 | 7.82 |
| CHEMBL2071209 | — | — | 1 | 7.80 |
| CHEMBL2071270 | — | — | 1 | 7.72 |
| CHEMBL2071272 | — | — | 1 | 7.60 |
| CHEMBL2071273 | — | — | 1 | 7.58 |
| CHEMBL2071274 | — | — | 1 | 7.57 |
| CHEMBL2071200 | — | — | 1 | 7.55 |
| CHEMBL2071194 | — | — | 1 | 7.54 |
| CHEMBL2071202 | — | — | 1 | 7.54 |
| CHEMBL2071211 | — | — | 1 | 7.51 |
| CHEMBL2071271 | — | — | 1 | 7.50 |
| CHEMBL2071214 | — | — | 1 | 7.50 |
| CHEMBL2071201 | — | — | 1 | 7.38 |
| CHEMBL2071205 | — | — | 1 | 7.37 |
| CHEMBL2071215 | — | — | 1 | 7.36 |
| CHEMBL2071206 | — | — | 1 | 7.35 |
| CHEMBL2071207 | — | — | 1 | 7.29 |
| CHEMBL1614709 | — | — | 1 | 7.27 |
| CHEMBL2071204 | — | — | 1 | 7.21 |
| CHEMBL2071203 | — | — | 1 | 7.18 |
| CHEMBL2071208 | — | — | 1 | 7.00 |
| CHEMBL2071212 | — | — | 1 | 6.93 |
| CHEMBL2071213 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1980297 | ILORASERTIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2071216 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2071210 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2071276 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2071275 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2071217 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2071277 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2071199 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2071209 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2071270 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2071272 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2071273 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2071274 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2071200 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2071202 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2071194 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2071211 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2071271 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2071214 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2071201 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL2071205 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2071215 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2071206 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2071207 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1614709 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL2071204 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL2071203 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL2071208 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL2071212 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL2071213 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL2071197 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL2071198 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL2071196 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL2071195 | — | IC50 | = | 294.0 | nM | 6.53 |