Assay Detail
Binding
CHEMBL2073527
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Inhibition of IKKbeta in mouse CIA model splenocytes assessed as inhibition of TNFalpha production after 72 hrs by ELISA
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta (CHEMBL6012) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of potent and selective rhodanine type IKKβ inhibitors by hit-to-lead strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.13 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL360077 | — | — | 1 | 5.75 |
| CHEMBL2070413 | — | — | 1 | 5.70 |
| CHEMBL2070414 | — | — | 1 | 5.40 |
| CHEMBL2070416 | — | — | 1 | 5.30 |
| CHEMBL2070412 | — | — | 1 | 5.30 |
| CHEMBL2070423 | — | — | 1 | 5.16 |
| CHEMBL2070426 | — | — | 1 | 5.16 |
| CHEMBL2070433 | — | — | 1 | 5.10 |
| CHEMBL2070424 | — | — | 1 | 5.10 |
| CHEMBL2070432 | — | — | 1 | 5.00 |
| CHEMBL2070411 | — | — | 1 | 4.92 |
| CHEMBL2070430 | — | — | 1 | 4.89 |
| CHEMBL2070418 | — | — | 1 | 4.52 |
| CHEMBL2070419 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL360077 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2070413 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2070414 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2070416 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2070412 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2070423 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2070426 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2070433 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2070424 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2070432 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2070411 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2070430 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2070418 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2070419 | — | IC50 | = | 30000.0 | nM | 4.52 |