Assay Detail
Functional
CHEMBL2073538
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Antiproliferative activity against human HCT116 cells expressing p53 after 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.41 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385064 | — | — | 1 | 8.70 |
| CHEMBL2070443 | — | — | 1 | 5.77 |
| CHEMBL2070445 | — | — | 1 | 5.58 |
| CHEMBL1096926 | — | — | 1 | 5.31 |
| CHEMBL2070441 | — | — | 1 | 4.79 |
| CHEMBL2070545 | — | — | 1 | 4.68 |
| CHEMBL1094607 | — | — | 1 | 4.65 |
| CHEMBL2070446 | — | — | 1 | 4.63 |
| CHEMBL2070447 | — | — | 1 | 4.60 |
| CHEMBL2070547 | — | — | 1 | - |
| CHEMBL2070546 | — | — | 1 | - |
| CHEMBL2070444 | — | — | 1 | - |
| CHEMBL2070442 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385064 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2070443 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL2070445 | — | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL1096926 | — | IC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL2070441 | — | IC50 | = | 16280.0 | nM | 4.79 |
| CHEMBL2070545 | — | IC50 | = | 20750.0 | nM | 4.68 |
| CHEMBL1094607 | — | IC50 | = | 22340.0 | nM | 4.65 |
| CHEMBL2070446 | — | IC50 | = | 23250.0 | nM | 4.63 |
| CHEMBL2070447 | — | IC50 | = | 24970.0 | nM | 4.60 |
| CHEMBL2070547 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL2070546 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL2070444 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL2070442 | — | IC50 | > | 15000.0 | nM | - |