Assay Detail
Functional
CHEMBL2075330
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of PAH uptake (PAH: 0.1uM) in membrane vesicles from MRP2-expressing HEK cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Subcellular | Membrane vesicle |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
ATP-binding cassette sub-family C member 2 (CHEMBL5748) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.86 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495936 | LEUKOTRIEN C4 | — | 1 | 5.48 |
| CHEMBL589366 | 3R14S-OCHRATOXIN A | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495936 | LEUKOTRIEN C4 | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL589366 | 3R14S-OCHRATOXIN A | IC50 | = | 58000.0 | nM | 4.24 |