Assay Detail
Functional
CHEMBL2075785
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of SN-38 uptake in bile canalicular membrane vesicles from SD rat
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Subcellular | Bile canalicular membrane vesicle |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
ATP-binding cassette sub-family C member 2 (CHEMBL2073676) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 5.63 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441687 | GLYCYRRHIZIN | 2.0 | 1 | 5.72 |
| CHEMBL453904 | SULFOBROMOPHTHALEIN SODIUM | -1.0 | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441687 | GLYCYRRHIZIN | Ki | = | 1910.0 | nM | 5.72 |
| CHEMBL453904 | SULFOBROMOPHTHALEIN SODIUM | Ki | = | 2870.0 | nM | 5.54 |