Assay Detail
Functional
CHEMBL2075786
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of Naf-GlcA uptake (Naf-GlcA: 0.1 uM) in bile canalicular membrane vesicles of Wistar rat
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Subcellular | Bile canalicular membrane vesicle |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
ATP-binding cassette sub-family C member 2 (CHEMBL2073676) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Hepatobiliary elimination of the peroxisome proliferator nafenopin by conjugation and subsequent ATP-dependent transport across the canalicular membrane.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.81 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495936 | LEUKOTRIEN C4 | — | 1 | 6.70 |
| CHEMBL213947 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495936 | LEUKOTRIEN C4 | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL213947 | — | IC50 | = | 12000.0 | nM | 4.92 |