Assay Detail
Functional
CHEMBL2076240
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | NIH-3T3-G185 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 8 | - | - |
| IC50 | 6 | 5.32 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1298 | NORVERAPAMIL | — | 1 | 6.05 |
| CHEMBL223643 | VALINOMYCIN | — | 1 | 5.50 |
| CHEMBL51149 | GALLOPAMIL | 2.0 | 1 | 5.50 |
| CHEMBL76447 | NOBILETIN | — | 1 | 4.94 |
| CHEMBL1393 | SPIRONOLACTONE | 4.0 | 1 | 4.63 |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | - |
| CHEMBL14130 | P-NITROPHENOL | — | 1 | - |
| CHEMBL79 | LIDOCAINE | 4.0 | 1 | - |
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | - |
| CHEMBL52440 | DEXTROMETHORPHAN | 4.0 | 1 | - |
| CHEMBL88 | CYCLOPHOSPHAMIDE ANHYDROUS | 4.0 | 1 | - |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | - |
| CHEMBL529 | AZITHROMYCIN | 4.0 | 1 | - |
| CHEMBL112 | ACETAMINOPHEN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1298 | NORVERAPAMIL | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL223643 | VALINOMYCIN | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL51149 | GALLOPAMIL | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL76447 | NOBILETIN | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL1393 | SPIRONOLACTONE | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL193 | NIFEDIPINE | IC50 | = | 113000.0 | nM | - |
| CHEMBL14130 | P-NITROPHENOL | Activity | - | — | - | |
| CHEMBL79 | LIDOCAINE | Activity | - | — | - | |
| CHEMBL139 | DICLOFENAC | Activity | - | — | - | |
| CHEMBL52440 | DEXTROMETHORPHAN | Activity | - | — | - | |
| CHEMBL88 | CYCLOPHOSPHAMIDE ANHYDROUS | Activity | - | — | - | |
| CHEMBL8 | CIPROFLOXACIN | Activity | - | — | - | |
| CHEMBL529 | AZITHROMYCIN | Activity | - | — | - | |
| CHEMBL112 | ACETAMINOPHEN | Activity | - | — | - |