Assay Detail
Functional
CHEMBL2076306
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in OCT1-expressing HeLa cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The interaction of n-tetraalkylammonium compounds with a human organic cation transporter, hOCT1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.62 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2074837 | TETRAHEXYLAMMONIUM | — | 1 | 5.52 |
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 4.63 |
| CHEMBL1236196 | TETRABUTHYLAMMONIUM | — | 1 | 4.28 |
| CHEMBL2074857 | TETRAPROPYLAMMONIUM | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2074837 | TETRAHEXYLAMMONIUM | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1294 | QUINIDINE | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL1236196 | TETRABUTHYLAMMONIUM | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL2074857 | TETRAPROPYLAMMONIUM | IC50 | = | 90000.0 | nM | 4.05 |