Assay Detail
Functional
CHEMBL2076360
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of Enalapril uptake in Oatp1-expressing HeLa cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier organic anion transporter family member 1A1 (CHEMBL1781859) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 5.10 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453904 | SULFOBROMOPHTHALEIN SODIUM | -1.0 | 1 | 5.70 |
| CHEMBL224867 | TAUROCHOLIC ACID | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453904 | SULFOBROMOPHTHALEIN SODIUM | Ki | = | 1980.0 | nM | 5.70 |
| CHEMBL224867 | TAUROCHOLIC ACID | Ki | = | 32000.0 | nM | 4.50 |