Assay Detail
Functional
CHEMBL2076904
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of Gly-Sar uptake in SKPT cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | SKPT |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 15 member 2 (CHEMBL1743125) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.71 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1644 | CEFADROXIL | 4.0 | 1 | 5.55 |
| CHEMBL1200356 | CYCLACILLIN | 4.0 | 1 | 4.41 |
| CHEMBL1727 | CEPHALEXIN ANHYDROUS | 4.0 | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1644 | CEFADROXIL | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL1200356 | CYCLACILLIN | Ki | = | 39100.0 | nM | 4.41 |
| CHEMBL1727 | CEPHALEXIN ANHYDROUS | Ki | = | 68200.0 | nM | 4.17 |