Assay Detail
Functional
CHEMBL2077006
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of GSSG uptake in membrane vesicle from MRP1-expressing HeLa cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HeLa |
| Subcellular | Membrane vesicle |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Multidrug resistance-associated protein 1 (CHEMBL3004) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.30 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495936 | LEUKOTRIEN C4 | — | 1 | 6.52 |
| CHEMBL15177 | MK-571 | — | 1 | 6.22 |
| CHEMBL2074814 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495936 | LEUKOTRIEN C4 | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL15177 | MK-571 | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL2074814 | — | Ki | = | 700.0 | nM | 6.16 |