Assay Detail
Functional
CHEMBL2077069
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of L-Lactate uptake (L-Lactate:30mM) in Xenopus laevis oocytes
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Xenopus laevis |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.54 | 4.68 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1909428 | p-Chloromercuribenzenesulfonate | — | 1 | 4.68 |
| CHEMBL45068 | PHLORETIN | — | 1 | 4.39 |
| CHEMBL1256759 | 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC ACID [NPPB] | — | 1 | - |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | — | 1 | - |
| CHEMBL76602 | alpha-CYANO-4-HYDROXYCINNAMIC ACID | — | 1 | - |
| CHEMBL2074592 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1909428 | p-Chloromercuribenzenesulfonate | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL45068 | PHLORETIN | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL1256759 | 5-NITRO-2-PHENYLPROPYLAMINOBENZOIC ACID [NPPB] | IC50 | = | 240000.0 | nM | - |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | IC50 | = | 970000.0 | nM | - |
| CHEMBL76602 | alpha-CYANO-4-HYDROXYCINNAMIC ACID | IC50 | = | 991000.0 | nM | - |
| CHEMBL2074592 | — | Activity | - | — | - |