Assay Detail
Functional
CHEMBL2077556
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from MRP2-expressing LLC PK1 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | LLC-PK1 |
| Subcellular | Membrane vesicle |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
ATP-binding cassette sub-family C member 2 (CHEMBL5748) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.05 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2074650 | — | — | 1 | 5.43 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 5.33 |
| CHEMBL15177 | MK-571 | — | 1 | 4.88 |
| CHEMBL1086218 | VALSPODAR | 3.0 | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2074650 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL160 | CYCLOSPORINE | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL15177 | MK-571 | Ki | = | 13100.0 | nM | 4.88 |
| CHEMBL1086218 | VALSPODAR | Ki | = | 28900.0 | nM | 4.54 |