Assay Detail
Functional
CHEMBL2077562
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of E1S uptake in OAT3-expressing S2 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | S2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.93 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52333 | ROLOFYLLINE | 3.0 | 1 | 5.43 |
| CHEMBL897 | PROBENECID | 4.0 | 1 | 5.05 |
| CHEMBL1231530 | BETAMIPRON | 2.0 | 1 | 4.32 |
| CHEMBL766 | CILASTATIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52333 | ROLOFYLLINE | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL897 | PROBENECID | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL1231530 | BETAMIPRON | Ki | = | 48300.0 | nM | 4.32 |
| CHEMBL766 | CILASTATIN | Ki | = | 231000.0 | nM | - |