Assay Detail
Functional
CHEMBL2077572
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of MPP+ uptake in Xenopus laevis oocytes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Xenopus laevis |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 1 (CHEMBL2073670) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.48 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1236196 | TETRABUTHYLAMMONIUM | — | 1 | 4.77 |
| CHEMBL2074857 | TETRAPROPYLAMMONIUM | — | 1 | 4.68 |
| CHEMBL9324 | TETRYLAMMONIUM | 2.0 | 1 | 4.00 |
| CHEMBL1209651 | TETRAMETHYLAMMONIUM | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1236196 | TETRABUTHYLAMMONIUM | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL2074857 | TETRAPROPYLAMMONIUM | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL9324 | TETRYLAMMONIUM | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL1209651 | TETRAMETHYLAMMONIUM | Ki | = | 905000.0 | nM | - |