Assay Detail
Functional
CHEMBL2077574
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | S2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 6 (CHEMBL1641347) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.89 | 5.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52333 | ROLOFYLLINE | 3.0 | 1 | 5.11 |
| CHEMBL897 | PROBENECID | 4.0 | 1 | 4.92 |
| CHEMBL1231530 | BETAMIPRON | 2.0 | 1 | 4.63 |
| CHEMBL766 | CILASTATIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52333 | ROLOFYLLINE | Ki | = | 7820.0 | nM | 5.11 |
| CHEMBL897 | PROBENECID | Ki | = | 12100.0 | nM | 4.92 |
| CHEMBL1231530 | BETAMIPRON | Ki | = | 23600.0 | nM | 4.63 |
| CHEMBL766 | CILASTATIN | Ki | = | 1470000.0 | nM | - |