Assay Detail
Functional
CHEMBL2077845
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of DNP-SG uptake in bile canalicular membrane vesicles from SD rat
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Subcellular | Bile canalicular membrane vesicle |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
ATP-binding cassette sub-family C member 2 (CHEMBL2073676) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.13 | 5.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2075009 | — | — | 1 | 5.99 |
| CHEMBL1743143 | — | — | 1 | 5.79 |
| CHEMBL2074578 | — | — | 1 | 4.74 |
| CHEMBL2074712 | — | — | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2075009 | — | Ki | = | 1030.0 | nM | 5.99 |
| CHEMBL1743143 | — | Ki | = | 1620.0 | nM | 5.79 |
| CHEMBL2074578 | — | Ki | = | 18300.0 | nM | 4.74 |
| CHEMBL2074712 | — | Ki | = | 96600.0 | nM | 4.01 |