Assay Detail
Functional
CHEMBL2078136
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TP_TRANSPORTER: inhibition of L-T4 uptake in Oatp14-expressing HEK293 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier organic anion transporter family member 1C1 (CHEMBL2073688) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.44 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559 | DEXTROTHYROXINE | 4.0 | 1 | 6.57 |
| CHEMBL1743304 | REVERSE TRIIODOTHYRONINE | — | 1 | 6.04 |
| CHEMBL41632 | TIRATRICOL | 3.0 | 1 | 5.67 |
| CHEMBL1544 | LIOTHYRONINE | 4.0 | 1 | 4.62 |
| CHEMBL494753 | ESTRONE SULFURIC ACID | 4.0 | 1 | 4.28 |
| CHEMBL1697724 | ESTRADIOL 17B GLUCURONIDE | — | 1 | - |
| CHEMBL224867 | TAUROCHOLIC ACID | — | 1 | - |
| CHEMBL897 | PROBENECID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559 | DEXTROTHYROXINE | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL1743304 | REVERSE TRIIODOTHYRONINE | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL41632 | TIRATRICOL | Ki | = | 2150.0 | nM | 5.67 |
| CHEMBL1544 | LIOTHYRONINE | Ki | = | 24200.0 | nM | 4.62 |
| CHEMBL494753 | ESTRONE SULFURIC ACID | Ki | = | 53100.0 | nM | 4.28 |
| CHEMBL1697724 | ESTRADIOL 17B GLUCURONIDE | Ki | > | 100000.0 | nM | - |
| CHEMBL224867 | TAUROCHOLIC ACID | Ki | = | 109000.0 | nM | - |
| CHEMBL897 | PROBENECID | Ki | = | 293000.0 | nM | - |