Compound Detail
CHEMBL1743304
REVERSE TRIIODOTHYRONINE Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1743304 |
| Name | REVERSE TRIIODOTHYRONINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HZCBWYNLGPIQRK-LBPRGKRZSA-N |
3
Targets
4
Activities
3
Assay Types
0
PK Parameters
12
Publications
0
Known Names
Molecular Properties
651.0
MW (Da)
3.95
ALogP
4
HBA
3
HBD
92.8
PSA (Ų)
0.43
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.42
Kd 1 meas. best 6.2
Ki 1 meas. best 6.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma CHEMBL235 | Kd | 6.2 | 6.2 | 630.0 | 1 |
| Solute carrier organic anion transporter family member 1C1 CHEMBL2073688 | Ki | 6.04 | 6.04 | 910.0 | 1 |
| Peroxisome proliferator-activated receptor gamma CHEMBL235 | EC50 | 5.42 | 5.42 | 3800.0 | 1 |
| Nuclear receptor subfamily 1 group I member 2 CHEMBL3401 | EC50 | 4.9 | 4.9 | 12600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma | Kd | = | 630.0 | nM | 6.2 | Binding affinity to recombinant PPARgamma LBD (unknown origin) by isothermal tit... | 32356658 |
| Solute carrier organic anion transporter family member 1C1 | Ki | = | 910.0 | nM | 6.04 | TP_TRANSPORTER: inhibition of L-T4 uptake in Oatp14-expressing HEK293 cells | 15166123 |
| Peroxisome proliferator-activated receptor gamma | EC50 | = | 3800.0 | nM | 5.42 | Agonist activity at recombinant human pFA-CMV fused PPARgamma expressed in HEK29... | 32356658 |
| Nuclear receptor subfamily 1 group I member 2 | EC50 | = | 12600.0 | nM | 4.9 | Competitive binding affinity to human PXR LBD (111 to 434) by TR-FRET assay | 20966043 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20966043 | 10.1124/dmd.110.035105 | Nuclear receptor subfamily 1 group I member 2 | 5 |
| 32356658 | 10.1021/acs.jmedchem.9b02150 | Peroxisome proliferator-activated receptor gamma | 4 |
| 12871948 | 10.1074/jbc.m300909200 | Monocarboxylate transporter 8 | 3 |
| 15166123 | 10.1210/en.2004-0058 | Solute carrier organic anion transporter family member 1C1 | 2 |
| 32356658 | 10.1021/acs.jmedchem.9b02150 | Retinoic acid receptor RXR-alpha | 2 |
| 12351693 | 10.1210/me.2001-0309 | Solute carrier organic anion transporter family member 1C1 | 1 |
| 9918867 | 10.1006/bbrc.1998.9974 | Hepatic sodium/bile acid cotransporter | 1 |
| 11316767 | 10.1210/endo.142.5.8115 | Solute carrier organic anion transporter family member 1A2 | 1 |
| 11316767 | 10.1210/endo.142.5.8115 | Solute carrier organic anion transporter family member 4A1 | 1 |
| 9918867 | 10.1006/bbrc.1998.9974 | Solute carrier organic anion transporter family member 1A1 | 1 |
| 25679268 | 10.1021/jm5015428 | Sodium- and chloride-dependent GABA transporter 1 | 1 |
| 34726055 | 10.1021/acs.jmedchem.1c00981 | Pyruvate kinase PKM | 1 |
Data from ChEMBL 36 via Core Engine