Assay Detail
Binding
CHEMBL4629574
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant PPARgamma LBD (unknown origin) by isothermal titration calorimetry
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPARγ.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 6.48 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL549748 | TETRAC | -1.0 | 1 | 6.96 |
| CHEMBL41632 | TIRATRICOL | 3.0 | 1 | 6.70 |
| CHEMBL1624 | LEVOTHYROXINE | 4.0 | 1 | 6.40 |
| CHEMBL1743304 | REVERSE TRIIODOTHYRONINE | — | 1 | 6.20 |
| CHEMBL1544 | LIOTHYRONINE | 4.0 | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL549748 | TETRAC | Kd | = | 110.0 | nM | 6.96 |
| CHEMBL41632 | TIRATRICOL | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL1624 | LEVOTHYROXINE | Kd | = | 400.0 | nM | 6.40 |
| CHEMBL1743304 | REVERSE TRIIODOTHYRONINE | Kd | = | 630.0 | nM | 6.20 |
| CHEMBL1544 | LIOTHYRONINE | Kd | = | 710.0 | nM | 6.15 |