Assay Detail
Functional
CHEMBL2078148
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of calcein-AM efflux in MDR1-expressing MDCK cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | MDCK |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.85 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL503 | LOVASTATIN | 4.0 | 1 | 5.00 |
| CHEMBL1064 | SIMVASTATIN | 4.0 | 1 | 5.00 |
| CHEMBL333687 | ATORVASTATIN LACTONE | — | 1 | 4.85 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 4.54 |
| CHEMBL1201391 | TENIVASTATIN | 2.0 | 1 | - |
| CHEMBL1201373 | LOVASTATIN ACID | -1.0 | 1 | - |
| CHEMBL1790017 | ATORVASTATIN ACID | — | 1 | - |
| CHEMBL1144 | PRAVASTATIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL503 | LOVASTATIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1064 | SIMVASTATIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL333687 | ATORVASTATIN LACTONE | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL1201391 | TENIVASTATIN | IC50 | - | — | - | |
| CHEMBL1201373 | LOVASTATIN ACID | IC50 | - | — | - | |
| CHEMBL1790017 | ATORVASTATIN ACID | IC50 | - | — | - | |
| CHEMBL1144 | PRAVASTATIN | IC50 | - | — | - |