Compound Detail
CHEMBL1201373
LOVASTATIN ACID Enter ChEMBL ID:
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CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)O)[C@H]21
Basic Information
| ChEMBL ID | CHEMBL1201373 |
| Name | LOVASTATIN ACID |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QLJODMDSTUBWDW-BXMDZJJMSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
7
Publications
5
Known Names
Molecular Properties
422.6
MW (Da)
3.72
ALogP
5
HBA
3
HBD
104.1
PSA (Ų)
0.46
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Single Enantiomer |
Activity Summary
IC50 1 meas. best 5.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Solute carrier organic anion transporter family member 1B1 CHEMBL1697668 | IC50 | 5.4 | 5.4 | 4000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Solute carrier organic anion transporter family member 1B1 | IC50 | = | 4000.0 | nM | 5.4 | TP_TRANSPORTER: inhibition of estradiol-17beta-glucuronide uptake(estradiol-17be... | 15616150 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15616150 | 10.1124/dmd.104.002477 | ATP-dependent translocase ABCB1 | 1 |
| 15616150 | 10.1124/dmd.104.002477 | ATP-binding cassette sub-family C member 2 | 1 |
| 15616150 | 10.1124/dmd.104.002477 | Solute carrier organic anion transporter family member 1B1 | 1 |
| - | 10.6019/CHEMBL3301361 | No relevant target | 1 |
| 36566630 | 10.1016/j.ejmech.2022.115010 | Rhizomucor pusillus | 1 |
| 36566630 | 10.1016/j.ejmech.2022.115010 | Rhizomucor miehei | 1 |
| 36566630 | 10.1016/j.ejmech.2022.115010 | Lichtheimia corymbifera | 1 |
Data from ChEMBL 36 via Core Engine